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Article

Significant under expression of the DosR regulon in M. tuberculosis complex lineage 6 in sputum.

Tuberculosis (Edinburgh, Scotland) - 1 May 2017

Ofori-Anyinam Boatema, Dolganov Gregory, Van Tran, Davis J Lucian, Walter Nicholas D, Garcia Benjamin J, Voskuil Marty, Fissette Kristina, Diels Maren, Driesen Michèle, Meehan Conor J, Yeboah-Manu Dorothy, Coscolla Mireia, Gagneux Sebastien, Antonio Martin, Schoolnik Gary, Gehre Florian, de Jong Bouke C

Abstract excerpt

Mycobacterium africanum lineage (L) 6 is an important pathogen in West Africa, causing up to 40% of pulmonary tuberculosis (TB). The biology underlying the clinical differences between M. africanum and M. tuberculosis sensu stricto remains poorly understood. We performed ex vivo expression of 2179 genes of the most geographically dispersed cause of human TB, M. tuberculosis L4 and the geographically restricted,...

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Identifiers

PMID: 28454650
DOI: 10.1016/j.tube.2017.03.001
PMCID: PMC5421582

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