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Response to Hypoxia and the Ensuing Dysregulation of Inflammation Impacts Mycobacterium tuberculosis Pathogenicity

12 Apr 2022

Abstract excerpt

Abstract Rationale Different Mycobacterium tuberculosis (Mtb) strains exhibit variable degrees of virulence in humans and animal models. Differing stress response strategies used by different strains of Mtb could influence virulence. Objectives We compared the virulence of two strains of Mtb with use in animal model research: CDC1551 and Erdman. Methods Rhesus macaques, which develop human-like tuberculosis...

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PMID: 35412961
DOI: 10.1164/rccm.202112-2747oc

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