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Article

Variation of the human mu-opioid receptor (OPRM1) gene predicts vulnerability to frustration.

Scientific reports - 14 Dec 2020

Daniel Alan M, Rushing Brenda G, Tapia Menchaca Karla Y

Abstract excerpt

Understanding the emotional reaction to loss, or frustration, is a critical problem for the field of mental health. Animal models of loss have pointed to the opioid system as a nexus of frustration, physical pain, and substance abuse. However, few attempts have been made to connect the results of animal models of loss to human behavior. Allelic differences in the human mu opioid receptor gene, notably the A118G...

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Identifiers

PMID: 33318511
DOI: 10.1038/s41598-020-78783-4
PMCID: PMC7736895

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Variation of the human mu-opioid receptor (OPRM1) gene predicts vulnerability to frustration.PMID 33318511Read ↗

Social hedonic capacity is associated with the A118G polymorphism of the mu-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients.Semantic proximity Read ↗

Mouse model of OPRM1 (A118G) polymorphism increases sociability and dominance and confers resilience to social defeat.Semantic proximity Read ↗

The OPRM1 A118G Polymorphism Revisited: Recent Developments and Implications for Personalized Treatment.Semantic proximity Read ↗

Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humans.Semantic proximity Read ↗

Consequences of the 118A&gt;G polymorphism in the OPRM1 gene: translation from bench to bedside?Semantic proximity Read ↗

Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism.Semantic proximity Read ↗

Functional mu opioid receptor polymorphism (OPRM1 A(118) G) associated with heroin use outcomes in Caucasian males: A pilot study.Semantic proximity Read ↗

Recovery profiles from reward downshift are correlated with operant licking maintained by alcohol, but not with genetic variation in the mu opioid receptor.Semantic proximity Read ↗

OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques.Semantic proximity Read ↗

Association between human μ‐opioid receptor gene polymorphism, pain tolerance, and opioid addictionSemantic proximity Read ↗

OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models.Semantic proximity Read ↗

Genetic variation in the behavioral effects of buprenorphine in female mice derived from a murine model of the OPRM1 A118G polymorphism.Semantic proximity Read ↗

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