Structural basis for self-assembly of a cytolytic pore lined by protein and lipid.

Abstract excerpt

Pore-forming toxins (PFT) are water-soluble proteins that possess the remarkable ability to self-assemble on the membrane of target cells, where they form pores causing cell damage. Here, we elucidate the mechanism of action of the haemolytic protein fragaceatoxin C (FraC), a α-barrel PFT, by determining the crystal structures of FraC at four different stages of the lytic mechanism, namely the water-soluble...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Lipids
• Share to Mutation
• Share to Protein Conformation