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Article

Perfringolysin O structure and mechanism of pore formation as a paradigm for cholesterol-dependent cytolysins.

Sub-cellular biochemistry - 1 Jan 2014

Johnson Benjamin B, Heuck Alejandro P

Abstract excerpt

Cholesterol-dependent cytolysins (CDCs) constitute a family of pore forming toxins secreted by Gram-positive bacteria. These toxins form transmembrane pores by inserting a large β-barrel into cholesterol-containing membrane bilayers. Binding of water-soluble CDCs to the membrane triggers the formation of oligomers containing 35-50 monomers. The coordinated insertion of more than seventy β-hairpins into the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Protein Structure, Tertiary

Source

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Identifiers

PMID: 24798008
DOI: 10.1007/978-94-017-8881-6_5
PMCID: PMC4836178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Perfringolysin O structure and mechanism of pore formation as a paradigm for cholesterol-dependent cytolysins.PMID 24798008Read ↗

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