Article

The pore conformation of lymphocyte perforin

2021-07-03

Abstract excerpt

Perforin is a pore-forming protein that facilitates rapid killing of pathogen-infected or cancerous cells by the immune system. Perforin is released from cytotoxic lymphocytes, together with pro-apoptotic granzymes, to bind to the plasma membrane of the target cell where it oligomerises and forms pores. The pores allow granzyme entry, which rapidly triggers the apoptotic death of the target cell. Here we present a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ed10f1d4-cbec-578a-b385-a3a261d5c19a
DOI: 10.1101/2021.07.03.450947

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The pore conformation of lymphocyte perforinDOI 10.1101/2021.07.03.450947Read

The molecular basis for perforin oligomerization and transmembrane pore assembly.Semantic proximity Read

Cryo-EM structure of the gasdermin A3 membrane pore.Semantic proximity Read

Mechanistic insights in to pore formation by the MACPF superfamilySemantic proximity Read

Perforin-mediated target-cell death and immune homeostasis.Semantic proximity Read

Structures of human pannexin 1 reveal ion pathways and mechanism of gating.Semantic proximity Read

The structure and function of mammalian membrane-attack complex/perforin-like proteinsSemantic proximity Read

Addressing the mysteries of perforin function.Semantic proximity Read

Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidaseSemantic proximity Read

Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidaseSemantic proximity Read

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.Semantic proximity Read

Functional dissection of the granzyme family: cell death and inflammationSemantic proximity Read

Structure of C8α-MACPF Reveals Mechanism of Membrane Attack in Complement Immune DefenseSemantic proximity Read