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The structure and function of mammalian membrane-attack complex/perforin-like proteins

22 Sept 2010

Abstract excerpt

The membrane-attack complex (MAC) of complement pathway and perforin (PF) are important tools deployed by the immune system to target pathogens. Both perforin and the C9 component of the MAC contain a common 'MACPF' domain and form pores in the cell membrane as part of their function. The MAC targets gram-negative bacteria and certain pathogenic parasites, while perforin, released by natural killer cells or...

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PMID: 20860583
DOI: 10.1111/j.1399-0039.2010.01566.x

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