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Structure of C8α-MACPF Reveals Mechanism of Membrane Attack in Complement Immune Defense

13 Sept 2007

Abstract excerpt

Membrane attack is important for mammalian immune defense against invading microorganisms and infected host cells. Proteins of the complement membrane attack complex (MAC) and the protein perforin share a common MACPF domain that is responsible for membrane insertion and pore formation. We determined the crystal structure of the MACPF domain of complement component C8alpha at 2.5 angstrom resolution and show that...

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PMID: 17872444
DOI: 10.1126/science.1147103

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