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FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors

25 Feb 2015

Abstract excerpt

The ability to escape apoptosis is a hallmark of cancer-initiating cells and a key factor of resistance to oncolytic therapy. Here, we identify FAM96A as a ubiquitous, evolutionarily conserved apoptosome-activating protein and investigate its potential pro-apoptotic tumor suppressor function in gastrointestinal stromal tumors (GISTs). Interaction between FAM96A and apoptotic peptidase activating factor 1 (APAF1)...

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PMID: 25716227
DOI: 10.1002/ijc.29498

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