Article
Human ACAP2 is a homolog of C. elegans CNT-1 that promotes apoptosis in cancer cells.
Cell cycle (Georgetown, Tex.) - 1 Jan 2015
Sullivan Kelly D, Nakagawa Akihisa, Xue Ding, Espinosa Joaquín M
Abstract excerpt
Activation of caspases is an integral part of the apoptotic cell death program. Collectively, these proteases target hundreds of substrates, leading to the hypothesis that apoptosis is "death by a thousand cuts". Recent work, however, has demonstrated that caspase cleavage of only a subset of these substrates directs apoptosis in the cell. One such example is C. elegans CNT-1, which is cleaved by CED-3 to...
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