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Article

Combined inhibition of Bcl-2 family members and YAP induces synthetic lethality in metastatic gastric cancer with RASA1 and NF2 deficiency.

Molecular cancer - 20 Sept 2023

Kwon Jong-Wan, Oh Jeong-Seop, Seok Sang Hyeok, An Hyeok-Won, Lee Yu Jin, Lee Na Yun, Ha Taehun, Kim Hyeon Ah, Yoon Gyeong Min, Kim Sung Eun, Oh Pu-Reum, Lee Su-Hyung, Voon Dominic C, Kim Dae-Yong, Park Jun Won

Abstract excerpt

BACKGROUND: Targetable molecular drivers of gastric cancer (GC) metastasis remain largely unidentified, leading to limited targeted therapy options for advanced GC. We aimed to identify molecular drivers for metastasis and devise corresponding therapeutic strategies. METHODS: We performed an unbiased in vivo genome-wide CRISPR/Cas9 knockout (KO) screening in peritoneal dissemination using genetically engineered...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37730636
DOI: 10.1186/s12943-023-01857-0
PMCID: PMC10510129

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