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Article

Apaf1 apoptotic function critically limits Sonic hedgehog signaling during craniofacial development.

Cell death and differentiation - 1 Nov 2013

Long A B, Kaiser W J, Mocarski E S, Caspary T

Abstract excerpt

Apaf1 is an evolutionarily conserved component of the apoptosome. In mammals, the apoptosome assembles when cytochrome c is released from mitochondria, binding Apaf1 in an ATP-dependent manner and activating caspase 9 to execute apoptosis. Here we identify and characterize a novel mouse mutant, yautja, and find it results from a leucine-to-proline substitution in the winged-helix domain of Apaf1. We show that...

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Source

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Identifiers

PMID: 23892366
DOI: 10.1038/cdd.2013.97
PMCID: PMC3792442

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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