Article

The Second Mitochondrial Activator of Caspases (SMAC) regulates growth, inflammation and mitochondrial integrity in cancer cells

2025-04-04

Abstract excerpt

SMAC is a mitochondrial intermembrane space protein, which is released during apoptosis and whose known function is antagonism of inhibitor of apoptosis proteins in the cytosol, to facilitate caspase activation. Recent data suggest that SMAC can also be released by sub-lethal signals in the apoptosis pathway, in the absence of cell death. We here explored potential functions of SMAC in non-apoptotic cells. We foun...

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Literature Corpus work: f9872ce9-e9ca-5949-ba03-4fe2f3b8b40d
DOI: 10.1101/2025.04.03.646995

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