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Article

Apaf1 in developmental apoptosis and cancer: how many ways to die?

Cellular and molecular life sciences : CMLS - 1 Oct 2001

Cecconi F, Gruss P

Abstract excerpt

Apaf1 has been described as the core of the apoptosome. Deficiency in murine Apaf1 leads to embryonic lethality with a phenotype affecting many aspects of developmental apoptosis. In the developing brain, Apaf1 is a death regulator of the neuronal founder cells. Combined intercrosses of mouse lines mutant for members of the mitochondrial death pathway are providing us with some clues about the relative regulation...

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Source

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Identifiers

PMID: 11706994
DOI: 10.1007/pl00000806
PMCID: PMC11337296

Genes

APAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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