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Article

ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt Pathway

26 Sept 2024

Abstract excerpt

Abstract The unfolded protein response maintains endoplasmic reticulum homeostasis by sensing protein-folding stress and orchestrating cellular adaptation via the endoplasmic reticulum transmembrane proteins IRE1, PERK, and ATF6. Malignant cells can co-opt IRE1 and PERK to sustain growth; however, the importance of ATF6 in cancer remains poorly deciphered. We observed elevated ATF6 transcriptional activity in...

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PMID: 39324706
DOI: 10.1158/2767-9764.crc-24-0268

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