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Article

Genetic polymorphism in ATG16L1 gene influences the response to adalimumab in Crohn's disease patients.

Pharmacogenomics - 1 Jan 2015

Koder Silvo, Repnik Katja, Ferkolj Ivan, Pernat Cvetka, Skok Pavel, Weersma Rinse K, Potočnik Uroš

Abstract excerpt

AIM: To see if SNPs could help predict response to biological therapy using adalimumab (ADA) in Crohn's disease (CD). MATERIALS & METHODS: IBDQ index and CRP levels were used to monitor therapy response. We genotyped 31 CD-associated genes in 102 Slovenian CD patients. RESULTS: The strongest association for treatment response defined as decrease in CRP levels was found for ATG16L1 SNP rs10210302. Additional SNPs...

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Identifiers

PMID: 25712183
DOI: 10.2217/pgs.14.172

Genes

ADA
CRP
CASP9
CCNY
PTGER4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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