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Article

Does Notch play a tumor suppressor role across diverse squamous cell carcinomas?

Cancer medicine - 1 Aug 2016

Zhang Min, Biswas Sangita, Qin Xin, Gong Wenrong, Deng Wenbing, Yu Hongjun

Abstract excerpt

The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro-oncogenic, typically depending on the cellular context. Squamous cell carcinoma (SCC) is a cancer of the squamous cell, which can occur in diverse human tissues. SCCs are one of the most frequent human malignancies for which the pathologic mechanisms remain elusive. Recent genomic analysis of diverse SCCs identified...

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Topics

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Share to Carcinoma, Squamous Cell
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein Binding

Share to Protein Interaction Domains and Motifs

Share to Receptors, Notch

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Source

Open in PubMed Open full text

Identifiers

PMID: 27228302
DOI: 10.1002/cam4.731
PMCID: PMC4884632

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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