Article
Common and complex Notch1 mutations in Chinese oral squamous cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2014
Song Xiaomeng, Xia Ronghui, Li Jiang, Long Zhifeng, Ren Hening, Chen Wantao, Mao Li
Abstract excerpt
PURPOSE: To determine Notch1 mutation status in oral squamous cell carcinoma (OSCC) from Chinese population and its potential clinical implications. EXPERIMENTAL DESIGN: Surgically resected OSCC tissues from 51 Chinese patients and 13 head and neck squamous cell carcinoma (HNSCC) cell lines were sequenced for mutations in the entire coding regions of Notch1 and TP53 using a next-generation sequencing platform....
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