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Article

Phenotype shift from atypical scrapie to CH1641 following experimental transmission in sheep.

PloS one - 1 Jan 2015

Simmons Marion M, Moore S Jo, Lockey Richard, Chaplin Melanie J, Konold Timm, Vickery Christopher, Spiropoulos John

Abstract excerpt

The interactions of host and infecting strain in ovine transmissible spongiform encephalopathies are known to be complex, and have a profound effect on the resulting phenotype of disease. In contrast to classical scrapie, the pathology in naturally-occurring cases of atypical scrapie appears more consistent, regardless of genotype, and is preserved on transmission within sheep homologous for the prion protein...

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Identifiers

PMID: 25710519
DOI: 10.1371/journal.pone.0117063
PMCID: PMC4339189

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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