PrP genotype and agent effects in scrapie: change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie.

doi:10.1099/0022-1317-75-5-989

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Article

PrP genotype and agent effects in scrapie: change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie.

The Journal of general virology - 1 May 1994

Goldmann W, Hunter N, Smith G, Foster J, Hope J

Abstract excerpt

Man and sheep are the two species in which spongiform encephalopathies occur naturally, and in which there are recognized genetic components that predispose an individual person or sheep to clinical disease. In both species mutations/polymorphisms in the PrP gene have been linked to the incidence...

Topics

Alleles
Animals
Base Sequence
Cattle
Codon
Encephalopathy, Bovine Spongiform
Genetic Variation
Genotype
Molecular Sequence Data
PrPSc Proteins
Prion Diseases
Prions
Scrapie
Sheep
Structure-Activity Relationship
Survival Analysis

Source

Open in PubMed

Identifiers

PMID: 7909834
DOI: 10.1099/0022-1317-75-5-989

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7909834-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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