Article
Disease phenotype in sheep after infection with cloned murine scrapie strains.
Prion - 1 Jan 2012
Sisó Silvia, Chianini Francesca, Eaton Sam L, Witz Janey, Hamilton Scott, Martin Stuart, Finlayson Jeanie, Pang Yvonne, Stewart Paula, Steele Philip, Dagleish Mark P, Goldmann Wilfred, Reid Hugh W, Jeffrey Martin, González Lorenzo
Abstract excerpt
Prion diseases exhibit different disease phenotypes in their natural hosts and when transmitted to rodents, and this variability is regarded as indicative of prion strain diversity. Phenotypic characterization of scrapie strains in sheep can be attempted by histological, immunohistochemical and biochemical approaches, but it is widely considered that strain confirmation and characterization requires rodent...
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