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Article

Circulation of Nor98 Atypical Scrapie in Portuguese Sheep Confirmed by Transmission of Isolates into Transgenic Ovine ARQ-PrP Mice.

International journal of molecular sciences - 28 Sept 2021

Casanova Mafalda, Machado Carla, Tavares Paula, Silva João, Fast Christine, Balkema-Buschmann Anne, Groschup Martin H, Orge Leonor

Abstract excerpt

Portugal was among the first European countries to report cases of Atypical Scrapie (ASc), the dominant form of Transmissible Spongiform Encephalopathy (TSE) in Portuguese small ruminants. Although the diagnostic phenotypes observed in Portuguese ASc cases seem identical to those described for Nor98, unequivocal identification requires TSE strain-typing using murine bioassays. In this regard, we initiated...

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Identifiers

PMID: 34638780
DOI: 10.3390/ijms221910441
PMCID: PMC8508621

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