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Article

Intraindividual genomic heterogeneity of high-grade serous carcinoma of the ovary and clinical utility of ascitic cancer cells for mutation profiling.

The Journal of pathology - 1 Jan 2017

Choi Youn Jin, Rhee Je-Keun, Hur Soo Young, Kim Min Sung, Lee Sung Hak, Chung Yeun-Jun, Kim Tae-Min, Lee Sug Hyung

Abstract excerpt

Intraindividual tumoural heterogeneity (ITH) is a hallmark of solid tumours and impedes accurate genomic diagnosis and selection of proper therapy. The aim of this study was to identify ITH of ovarian high-grade serous carcinomas (OSCs) and to determine the utility of ascitic cancer cells as a resource for mutation profiling in spite of ITH. We performed whole-exome sequencing, copy number profiling and DNA...

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Identifiers

PMID: 27741368
DOI: 10.1002/path.4819

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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