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Article

Increased susceptibility of estrogen-induced bladder outlet obstruction in a novel mouse model.

Laboratory investigation; a journal of technical methods and pathology - 1 May 2015

Tam Neville Ngai-Chung, Zhang Xiang, Xiao Hong, Song Dan, Levin Linda, Meller Jarek, Ho Shuk-Mei

Abstract excerpt

Disorders of the prostate and lower urinary tract are common in elderly men. We investigated the role of metallothionein-1 (MT1) in prostate carcinogenesis by generating a prostate-specific, MT1-expressing mouse. Unexpectedly, genomic analyses revealed that a 12.1-kb genomic region harboring several conserved noncoding elements was unintentionally deleted, upstream of the transgene integration site in the mouse,...

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Source

Identifiers

PMID: 25706094
DOI: 10.1038/labinvest.2015.30

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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