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Brca2 and Trp53 Deficiency Cooperate in the Progression of Mouse Prostate Tumourigenesis

24 Jun 2010

Abstract excerpt

Epidemiological studies have shown that one of the strongest risk factors for prostate cancer is a family history of the disease, suggesting that inherited factors play a major role in prostate cancer susceptibility. Germline mutations in BRCA2 predispose to breast and ovarian cancer with its predominant tumour suppressor function thought to be the repair of DNA double-strand breaks. BRCA2 has also been...

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PMID: 20585617
DOI: 10.1371/journal.pgen.1000995

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