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Article

Molecular mechanisms of bladder outlet obstruction in transgenic male mice overexpressing aromatase (Cyp19a1).

The American journal of pathology - 1 Mar 2011

Lin Wei, Rahman Nafis A, Lin Jian, Zhang Hua, Gou Kemian, Yu Wanpeng, Zhu Dahai, Li Ning, Huhtaniemi Ilpo, Li Xiangdong

Abstract excerpt

We investigated the etiology and molecular mechanisms of bladder outlet obstruction (BOO). Transgenic (Tg) male mice overexpressing aromatase (Cyp19a1) under the ubiquitin C promoter in the estrogen-susceptible C57Bl/6J genetic background (AROM+/6J) developed inguinal hernia by 2 months and severe BOO by 9 to 10 months, with 100% penetrance. These mice gradually developed uremia, renal failure, renal retention,...

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Identifiers

PMID: 21356374
DOI: 10.1016/j.ajpath.2010.11.056
PMCID: PMC3070572

Genes

PCNA
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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