Article
In Utero and Lactational TCDD Exposure Increases Susceptibility to Lower Urinary Tract Dysfunction in Adulthood.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Apr 2016
Ricke William A, Lee Calvin W, Clapper Tyler R, Schneider Andrew J, Moore Robert W, Keil Kimberly P, Abler Lisa L, Wynder Jalissa L, López Alvarado Arnaldo, Beaubrun Isaac, Vo Jenny, Bauman Tyler M, Ricke Emily A, Peterson Richard E, Vezina Chad M
Abstract excerpt
Benign prostatic hyperplasia, prostate cancer, and changes in the ratio of circulating testosterone and estradiol often occur concurrently in aging men and can lead to lower urinary tract (LUT) dysfunction. To explore the possibility of a fetal basis for the development of LUT dysfunction in adulthood, Tg(CMV-cre);Nkx3-1(+/-);Pten(fl/+) mice, which are genetically predisposed to prostate neoplasia, were exposedin...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.