Article

Comparative RNA-sequencing analysis of the prostate in a mouse model of benign prostatic hyperplasia with bladder outlet obstruction

2022-11-29

Abstract excerpt

In aging men, BPH is a chronic disease that leads to progressive lower urinary tract symptoms (LUTS) caused by obstruction of the bladder outlet (BOO). Patients with LUTS (such as frequency and urgency) and complications of BOO (such as hydronephrosis and bladder stones) are at risk of serious health problems. Nevertheless, clinical treatment is complicated and uncertain. BPH is caused by hormonal imbalances relat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b915c639-45c5-562c-bc34-3d14f558fcea
DOI: 10.21203/rs.3.rs-2296936/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comparative RNA-sequencing analysis of the prostate in a mouse model of benign prostatic hyperplasia with bladder outlet obstructionDOI 10.21203/rs.3.rs-2296936/v1Read

Molecular mechanisms of bladder outlet obstruction in transgenic male mice overexpressing aromatase (Cyp19a1).Semantic proximity Read

A genetic study to identify pathogenic mechanisms and drug targets for benign prostatic hyperplasia: a multi-omics Mendelian randomization study.Semantic proximity Read

Genomic analysis of benign prostatic hyperplasia implicates cellular relandscaping in disease pathogenesisSemantic proximity Read

[Molecular and endocrinological mechanism of benign prostatic hyperplasia and prostate cancer].Semantic proximity Read

Epidemiological investigation of sex hormones and their metabolism-related gene single nucleotide polymorphisms in patients with benign prostatic hyperplasia complicated with late-onset hypogonadism: a retrospective cohort studySemantic proximity Read

Molecular Profiling of Inflammatory Processes in a Mouse Model of IC/BPS: From the Complete Transcriptome to Major Sex-Related Histological Features of the Urinary BladderSemantic proximity Read

The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition.Semantic proximity Read

Androgen receptor‐related diseases: what do we know?Semantic proximity Read

Increased susceptibility of estrogen-induced bladder outlet obstruction in a novel mouse model.Semantic proximity Read

The mouse prostate: a basic anatomical and histological guideline.Semantic proximity Read

Integrative genomic, transcriptomic, and epigenomic analyses of benign prostatic hyperplasia reveal new options for therapySemantic proximity Read

Urinary miRNA profiles discriminate between obstruction-induced bladder dysfunction and healthy controlsSemantic proximity Read