Article
Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype.
International journal of cancer - 15 Nov 2010
Shi Zhanquan, Dragin Nadine, Miller Marian L, Stringer Keith F, Johansson Elisabet, Chen Jing, Uno Shigeyuki, Gonzalez Frank J, Rubio Carlos A, Nebert Daniel W
Abstract excerpt
Benzo[a]pyrene (BaP) is a prototypical polycyclic aromatic hydrocarbon (PAH) found in combustion processes. Cytochrome P450 1A1 and 1B1 enzymes (CYP1A1 and CYP1B1) can both detoxify PAHs and activate them to cancer-causing reactive intermediates. Following high dosage of oral BaP (125 mg/kg/day), ablation of the mouse Cyp1a1 gene causes immunosuppression and death within ∼28 days, whereas Cyp1(+/+) wild-type mice...
Topics
- Adenocarcinoma
- Administration, Oral
- Animals
- Aryl Hydrocarbon Hydroxylases
- Benzo(a)pyrene
- Carcinoma, Squamous Cell
- Cytochrome P-450 CYP1A1
- Cytochrome P-450 CYP1B1
- Female
- Genotype