Article
Generation of a Novel T Cell Specific Interleukin-1 Receptor Type 1 Conditional Knock Out Mouse Reveals Intrinsic Defects in Survival, Expansion and Cytokine Production of CD4 T Cells.
PloS one - 1 Jan 2016
Mufazalov Ilgiz A, Regen Tommy, Schelmbauer Carsten, Kuschmann Janina, Muratova Alisa M, Nikolaev Alexei, Müller Werner, Pinteaux Emmanuel, Waisman Ari
Abstract excerpt
Interleukin-1 (IL-1) plays a crucial role in numerous inflammatory diseases via action on its only known signaling IL-1 receptor type 1 (IL-1R1). To investigate the role of IL-1 signaling in selected cell types, we generated a new mouse strain in which exon 5 of the Il1r1 gene is flanked by loxP sites. Crossing of these mice with CD4-Cre transgenic mice resulted in IL-1R1 loss of function specifically in T cells....
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