Article
Phenotypic and functional characterization of mice that lack the type I receptor for IL-1.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 1997
Glaccum M B, Stocking K L, Charrier K, Smith J L, Willis C R, Maliszewski C, Livingston D J, Peschon J J, Morrissey P J
Abstract excerpt
IL-1 alpha and IL-1 beta bind to receptors termed the type I and type II IL-1 receptors. The type I IL-1 receptor is responsible for specific signaling, while the type II IL-1 receptor functions as a nonsignaling decoy receptor. To determine the effect of a defect in IL-1-mediated signaling, mice have been produced with a genetically disrupted type I IL-1 receptor gene. Mice lacking type I IL-1 receptors are of...
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