Article
Generation and Characterization of Mice Expressing a Conditional Allele of the Interleukin-1 Receptor Type 1.
PloS one - 1 Jan 2016
Robson Matthew J, Zhu Chong-Bin, Quinlan Meagan A, Botschner David A, Baganz Nicole L, Lindler Kathryn M, Thome Jason G, Hewlett William A, Blakely Randy D
Abstract excerpt
The cytokines IL-1α and IL-1β exert powerful pro-inflammatory actions throughout the body, mediated primarily by the intracellular signaling capacity of the interleukin-1 receptor (IL-1R1). Although Il1r1 knockout mice have been informative with respect to a requirement for IL-1R1 signaling in inflammatory events, the constitutive nature of gene elimination has limited their utility in the assessment of temporal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.