Article

Multimodal transcriptomics and calcium imaging reveal a novel subset of polymodal nociceptors expressing the interleukin 1 receptor in mice

2026-07-24

Abstract excerpt

<h4>ABSTRACT</h4> We previously established that sensory neurons in the mouse dorsal root ganglia (DRG) express a functional receptor for the proinflammatory cytokine interleukin (IL)-1. We also demonstrated that deletion of the IL-1 receptor type 1 gene, Il1r1 , in TRPV1-expressing (+) neurons prevented pain in models of chronic inflammatory diseases such as multiple sclerosis, rheumatoid arthritis and osteoart...

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Literature Corpus work: 0c987b26-1e27-57f3-aeea-08737ed48b50
DOI: 10.64898/2026.07.21.739828

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