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Article

A CRISPR/Cas9-engineered mouse carrying a conditional knockout allele for the early growth response-1 transcription factor.

Genesis (New York, N.Y. : 2000) - 1 Jul 2023

Maurya Vineet K, Ying Yan, Lanza Denise G, Heaney Jason D, Lydon John P

Abstract excerpt

Early growth response 1 (EGR1) mediates transcriptional programs that are indispensable for cell division, differentiation, and apoptosis in numerous physiologies and pathophysiologies. Whole-body EGR1 knockouts in mice (Egr1KO ) have advanced our understanding of EGR1 function in an in vivo context. To extend the utility of the mouse to investigate EGR1 responses in a tissue- and/or cell-type-specific manner, we...

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Identifiers

PMID: 36949241
DOI: 10.1002/dvg.23515
PMCID: PMC10514223

Genes

EGR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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