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Controlled Delivery of a Neurotrophic Factor in the Adult Mouse Brain Using Engineered Microglia

2025-10-07

Abstract excerpt

<h4>ABSTRACT</h4> Microglia, the resident immune cells of the central nervous system, have been proposed as vehicles for delivering therapeutic biologics. These cells can be genetically engineered in vitro and transplanted into host animals following ablation of endogenous microglia, enabling repopulation of the brain parenchyma. However, current replacement strategies often rely on radiation or transgenic models...

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Literature Corpus work
660e3934-ae98-50f2-8b84-fd2edbfbe553
DOI
10.1101/2025.10.06.680702
Open publication

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Controlled Delivery of a Neurotrophic Factor in the Adult Mouse Brain Using Engineered MicrogliaDOI 10.1101/2025.10.06.680702
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