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Characterization of a conditional interleukin‐1 receptor 1 mouse mutant using the Cre/LoxP system

22 Dec 2015

Abstract excerpt

IL-1 is a key cytokine known to drive chronic inflammation and to regulate many physiological, immunological, and neuroimmunological responses via actions on diverse cell types of the body. To determine the mechanisms of IL-1 actions as part of the inflammatory response in vivo, we generated a conditional IL-1 receptor 1 (IL-1R1) mouse mutant using the Cre/LoxP system (IL-1R1(fl/fl) ). In the mutant generated,...

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PMID: 26692072
DOI: 10.1002/eji.201546075

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