Article

Increased activity of IRE1 improves the clinical presentation of EAE

2023-04-20

Abstract excerpt

Activation of the ER stress sensor IRE1α contributes to neuronal development and is known to induce neuronal remodeling in vitro and in vivo . On the other hand, excessive IRE1 activity is often detrimental and may contribute to neurodegeneration. To determine the consequences of increased activation of IRE1α, we used a mouse model expressing a C148S variant of IRE1α with increased and sustained activation. Surp...

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Literature Corpus work: f94e9391-a747-5542-9c0e-50b5f8bdc735
DOI: 10.1101/2023.04.19.537391

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