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Article

Platelet adhesion to podoplanin under flow is mediated by the receptor CLEC-2 and stabilised by Src/Syk-dependent platelet signalling.

Thrombosis and haemostasis - 1 May 2015

Navarro-Núñez Leyre, Pollitt Alice Y, Lowe Kate, Latif Arusa, Nash Gerard B, Watson Steve P

Abstract excerpt

Platelet-specific deletion of CLEC-2, which signals through Src and Syk kinases, or global deletion of its ligand podoplanin results in blood-filled lymphatics during mouse development. Platelet-specific Syk deficiency phenocopies this defect, indicating that platelet activation is required for lymphatic development. In the present study, we investigated whether CLEC-2-podoplanin interactions could support...

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Source

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Identifiers

PMID: 25694214
DOI: 10.1160/TH14-09-0762
PMCID: PMC4990172

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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