Article
Mice lacking the SLAM family member CD84 display unaltered platelet function in hemostasis and thrombosis.
PloS one - 1 Jan 2014
Hofmann Sebastian, Braun Attila, Pozgaj Rastislav, Morowski Martina, Vögtle Timo, Nieswandt Bernhard
Abstract excerpt
BACKGROUND: Platelets are anuclear cell fragments derived from bone marrow megakaryocytes that safeguard vascular integrity by forming thrombi at sites of vascular injury. Although the early events of thrombus formation--platelet adhesion and aggregation--have been intensively studied, less is known about the mechanisms and receptors that stabilize platelet-platelet interactions once a thrombus has formed. One...
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