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Article

Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.

The Journal of cell biology - 15 Apr 2002

Obergfell Achim, Eto Koji, Mocsai Attila, Buensuceso Charito, Moores Sheri L, Brugge Joan S, Lowell Clifford A, Shattil Sanford J

Abstract excerpt

Integrins regulate cell adhesion and motility through tyrosine kinases, but initiation of this process is poorly understood. We find here that Src associates constitutively with integrin alphaIIbbeta3 in platelets. Platelet adhesion to fibrinogen caused a rapid increase in alphaIIbbeta3-associated Src activity, and active Src localized to filopodia and cell edges. Csk, which negatively regulates Src by...

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Identifiers

PMID: 11940607
DOI: 10.1083/jcb.200112113
PMCID: PMC2199242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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