Article

Antibody-mediated depletion of human CLEC-2 in a novel humanised mouse model

2021-10-03

Abstract excerpt

Platelet C-type lectin-like receptor 2 (CLEC-2) has been proposed as a potential anti-thrombotic target as genetic or antibody-mediated receptor deficiency prevents occlusive thrombus formation in mice. This occurs through interaction with an unknown ligand as the endogenous ligand podoplanin is not present in the vasculature. However, the CLEC-2-podoplanin interaction does have an important role in tumour metasta...

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Literature Corpus work: 1ee5e2b5-38de-5ce7-9255-11908daa1d2c
DOI: 10.1101/2021.10.03.462933

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