Article
In-silico identification and functional validation of allele-dependent AR enhancers.
Oncotarget - 10 Mar 2015
Garritano Sonia, Romanel Alessandro, Ciribilli Yari, Bisio Alessandra, Gavoci Antoneta, Inga Alberto, Demichelis Francesca
Abstract excerpt
Androgen Receptor (AR) and Estrogen Receptors (ERs) are key nuclear receptors that can cooperate in orchestrating gene expression programs in multiple tissues and diseases, targeting binding elements in promoters and distant enhancers. We report the unbiased identification of enhancer elements bound by AR and ER-α whose activity can be allele-specific depending on the status of nearby Single Nucleotide...
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