Article
Functional mapping of androgen receptor enhancer activity.
Genome biology - 11 May 2021
Huang Chia-Chi Flora, Lingadahalli Shreyas, Morova Tunc, Ozturan Dogancan, Hu Eugene, Yu Ivan Pak Lok, Linder Simon, Hoogstraat Marlous, Stelloo Suzan, Sar Funda, van der Poel Henk, Altintas Umut Berkay, Saffarzadeh Mohammadali, Le Bihan Stephane, McConeghy Brian, Gokbayrak Bengul, Feng Felix Y, Gleave Martin E, Bergman Andries M, Collins Colin, Hach Faraz, Zwart Wilbert, Emberly Eldon, Lack Nathan A
Abstract excerpt
BACKGROUND: Androgen receptor (AR) is critical to the initiation, growth, and progression of prostate cancer. Once activated, the AR binds to cis-regulatory enhancer elements on DNA that drive gene expression. Yet, there are 10-100× more binding sites than differentially expressed genes. It is unclear how or if these excess binding sites impact gene transcription. RESULTS: To characterize the regulatory logic of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.