Article

Functional mapping of androgen receptor enhancer activity

2020-08-18

Abstract excerpt

Androgen receptor (AR) is critical to the initiation, growth and progression of almost all prostate cancers. Once activated, the AR binds to cis -regulatory enhancer elements on DNA that drive gene expression. Yet, there are 10-100x more binding sites than differentially expressed genes. It still remains unclear how individual sites contribute to AR-mediated transcription. While descriptive functional genomic app...

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Literature Corpus work: 963ceb9f-2977-579a-bced-52fa73e3ac19
DOI: 10.1101/2020.08.18.255232

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