Evolutionary Action Score of TP53 Coding Variants Is Predictive of Platinum Response in Head and Neck Cancer Patients.

doi:10.1158/0008-5472.CAN-14-2729

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Evolutionary Action Score of TP53 Coding Variants Is Predictive of Platinum Response in Head and Neck Cancer Patients.

Cancer research - 1 Apr 2015

Osman Abdullah A, Neskey David M, Katsonis Panagiotis, Patel Ameeta A, Ward Alexandra M, Hsu Teng-Kuei, Hicks Stephanie C, McDonald Thomas O, Ow Thomas J, Alves Marcus Ortega, Pickering Curtis R, Skinner Heath D, Zhao Mei, Sturgis Eric M, Kies Merrill S, El-Naggar Adel, Perrone Federica, Licitra Lisa, Bossi Paolo, Kimmel Marek, Frederick Mitchell J, Lichtarge Olivier, Myers Jeffrey N

Abstract excerpt

TP53 is the most frequently altered gene in head and neck squamous cell carcinoma (HNSCC), with mutations occurring in over two thirds of cases; however, the predictive response of these mutations to cisplatin-based therapy remains elusive. In the current study, we evaluate the ability of the Evolutionary Action score of TP53-coding variants (EAp53) to predict the impact of TP53 mutations on response to...

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PMID: 25691460
DOI: 10.1158/0008-5472.CAN-14-2729
PMCID: PMC4615655

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