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Article

Evolutionary Action Score of <i>TP53</i> Mutations: Integrated Clinico-pathologic And Protein Structural Analysis in Myelodysplastic Syndromes

2020-07-08

Abstract excerpt

<h4>ABSTRACT</h4> To determine the impact of TP53 mutations on the phenotype and outcome of myelodysplastic syndromes, we quantified the deleterious effects of missense TP53 mutations using the computationally-derived evolutionary action score (higher score indicates worse impact), based on the phylogenetic divergence of the sequence position and amino acid change perturbation, and correlated with clinico-patho...

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Literature Corpus work
895be0b0-4de3-5b3f-a83c-b959f604efae
DOI
10.1101/2020.07.08.194365
Open publication

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Evolutionary Action Score of <i>TP53</i> Mutations: Integrated Clinico-pathologic And Protein Structural Analysis in Myelodysplastic SyndromesDOI 10.1101/2020.07.08.194365
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