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Article

ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis.

Journal of lipid research - 1 Apr 2015

Siow Deanna, Sunkara Manjula, Dunn Teresa M, Morris Andrew J, Wattenberg Binks

Abstract excerpt

The ORM1 (Saccharomyces cerevisiae)-like proteins (ORMDLs) and their yeast orthologs, the Orms, are negative homeostatic regulators of the initiating enzyme in sphingolipid biosynthesis, serine palmitoyltransferase (SPT). Genome-wide association studies have established a strong correlation between elevated expression of the endoplasmic reticulum protein ORMDL3 and risk for childhood asthma. Here we test the...

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Identifiers

PMID: 25691431
DOI: 10.1194/jlr.M057539
PMCID: PMC4373746

Genes

ORMDL3
ORM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis.PMID 25691431Read ↗

ORMDL3 expression levels have no influence on the activity of serine palmitoyltransferase.Semantic proximity Read ↗

Sphingolipids and Asthma.Semantic proximity Read ↗

Expression of the ORMDLS, modulators of serine palmitoyltransferase, is regulated by sphingolipids in mammalian cells.Semantic proximity Read ↗

Airway reactivity and sphingolipids—implications for childhood asthmaSemantic proximity Read ↗

Orm proteins integrate multiple signals to maintain sphingolipid homeostasis.Semantic proximity Read ↗

The ORMDL3 Asthma Gene Regulates ICAM1 and Has Multiple Effects on Cellular InflammationSemantic proximity Read ↗

Structural insights into the assembly and substrate selectivity of human SPT-ORMDL3 complex.Semantic proximity Read ↗

At last - linking ORMDL3 polymorphisms, decreased sphingolipid synthesis, and asthma susceptibility.Semantic proximity Read ↗

Childhood asthma is associated with mutations and gene expression differences of ORMDL genes that can interact.Semantic proximity Read ↗

Subunit composition of the mammalian serine-palmitoyltransferase defines the spectrum of straight and methyl-branched long-chain basesSemantic proximity Read ↗

Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control.Semantic proximity Read ↗

Novel insights into in vivo functions of the asthma susceptibility gene ORMDL3Semantic proximity Read ↗

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