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Article

ORMDL3 expression levels have no influence on the activity of serine palmitoyltransferase.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2016

Zhakupova Assem, Debeuf Nincy, Krols Michiel, Toussaint Wendy, Vanhoutte Leen, Alecu Irina, Kutalik Zoltán, Vollenweider Peter, Ernst Daniela, von Eckardstein Arnold, Lambrecht Bart N, Janssens Sophie, Hornemann Thorsten

Abstract excerpt

ORMDL proteins are believed to be negative regulators of serine palmitoyltransferase (SPT), which catalyzes the first and rate limiting step in sphingolipid (SL) de novo synthesis. Several single-nucleotide polymorphisms (SNPs) that are close to the ORMDL3 locus have been reported to increase ORMDL3 expression and to be associated with an elevated risk for early childhood asthma; however, the direct effect of...

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Protein Isoforms

Serine C-Palmitoyltransferase

Source

Identifiers

PMID: 27645259
DOI: 10.1096/fj.201600639R

Genes

ORMDL3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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ORMDL3 expression levels have no influence on the activity of serine palmitoyltransferase.PMID 27645259Read ↗

Sphingolipids and Asthma.Semantic proximity Read ↗

ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis.Semantic proximity Read ↗

At last - linking ORMDL3 polymorphisms, decreased sphingolipid synthesis, and asthma susceptibility.Semantic proximity Read ↗

Airway reactivity and sphingolipids—implications for childhood asthmaSemantic proximity Read ↗

Subunit composition of the mammalian serine-palmitoyltransferase defines the spectrum of straight and methyl-branched long-chain basesSemantic proximity Read ↗

Childhood asthma is associated with mutations and gene expression differences of ORMDL genes that can interact.Semantic proximity Read ↗

The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in miceSemantic proximity Read ↗

Increased expression of serine palmitoyl transferase and ORMDL3 polymorphism are associated with eosinophilic inflammation and airflow limitation in aspirin-exacerbated respiratory disease.Semantic proximity Read ↗

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Expression of the ORMDLS, modulators of serine palmitoyltransferase, is regulated by sphingolipids in mammalian cells.Semantic proximity Read ↗

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