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Article

Expression of the ORMDLS, modulators of serine palmitoyltransferase, is regulated by sphingolipids in mammalian cells.

The Journal of biological chemistry - 2 Jan 2015

Gupta Sita D, Gable Kenneth, Alexaki Aikaterini, Chandris Panagiotis, Proia Richard L, Dunn Teresa M, Harmon Jeffrey M

Abstract excerpt

The relationship between serine palmitoyltransferase (SPT) activity and ORMDL regulation of sphingolipid biosynthesis was investigated in mammalian HEK293 cells. Each of the three human ORMDLs reduced the increase in long-chain base synthesis seen after overexpression of wild-type SPT or SPT containing the C133W mutation in hLCB1, which produces the non-catabolizable sphingoid base, 1-deoxySa. ORMDL-dependent...

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Identifiers

PMID: 25395622
DOI: 10.1074/jbc.M114.588236
PMCID: PMC4281770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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