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Article

Double minute amplification of mutant PDGF receptor α in a mouse glioma model.

Scientific reports - 16 Feb 2015

Zou Hongyan, Feng Rui, Huang Yong, Tripodi Joseph, Najfeld Vesna, Tsankova Nadejda M, Jahanshahi Maryam, Olson Lorin E, Soriano Philippe, Friedel Roland H

Abstract excerpt

In primary brain tumors, oncogenes are frequently amplified and maintained on extrachromosomal DNA as double minutes (DM), but the underlying mechanisms remain poorly understood. We have generated a mouse model of malignant glioma based on knock-in of a mutant PDGF receptor α (PDGFRα) that is exp...

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Identifiers

PMID: 25683249
DOI: 10.1038/srep08468
PMCID: PMC4329559

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25683249-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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